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CPA

Combating Resistance in the Treatment of Infectious Diseases by Promoting Judicious/Rational Use of Anti-infective Drugs

Short description

CPA facilitates collaborative research on optimal use of anti-infective drugs as a means to combat antimicrobialresistance.

The research projects under CPA will help fill important gaps in knowledge about locally-relevant, real-world hospital practice and ways in which scientific training on appropriate drug use may assist healthcare professionals optimize/increase benefits to the individual patient alongside promoting public health.

Three PhD students from Zimbabwe, Zambia and Malawi will conduct research in the fields of drug safety, clinical pharmacology, pharmacogenetics and individualized therapy. The project will enable a situation analysis of prescription practices and resistance in healthcare facilities and strengthen transfer of knowledge on optimal and judicious use of anti-infective drugs.

This project will facilitate research in the fields of drug safety, clinical pharmacology, pharmacogenetics and individualized therapy.  The project will enable a situation analysis of prescription practices and resistance in healthcare facilities and strengthen transfer of knowledge on optimal and judicious use of anti-infective drugs.

CPA aims to support research carried out by African researchers and establish a network for the coordinated optimization of anti-infective drug therapy through facilitating/guiding:

  • Scientific training in the field of judicious use of anti-infective drugs, therapeutic drug monitoring (TDM), pharmacogenetics and clinical pharmacology.
  • Collection of data reflecting locally-relevant, real-world hospital practice in selected healthcare facilities in African partner countries.
  • Initiation and establishment of a network for the coordinated research for appraisal of use and optimization of relevant anti-infective drug therapy in local hospitals.
  • Means to increase awareness and assist healthcare professionals to increase benefits to the individual patient alongside promoting (national) public health.

Aims of the project

The overall goal of this project is to launch collaborative research and thereby initiate and establish a network for the coordinated optimization of anti-infective drug use. The pharmacogenetic analyses planned will advance awareness of modern medical methods of patient diagnostics into the clinical context. They willinvestigatein which way/how and ifspecific genetic polymorphisms in drug metabolizing enzymes existing in the population of sub-Saharan Africa may affect negatively drug exposure in patients, and thereby contribute to the spread of drug resistance. The project will foster international collaboration by enabling knowledge transfer within the area of appropriate drug use.  Keeping in mind potential resource constraints, the e-learning will be tailored to guide healthcare professionals by encouraging the safe and appropriate use of anti-infective drug use in hospitals, thereby ultimately enhancing patient safety. The e-learning tool could be further adapted to other healthcare settings.

Infos

Supporting institution

Federal Institute for Drugs and Medical Devices (BfArM)

Partner countries

Zimbabwe, Zambia, Malawi

Partner in Zimbabwe

African Institute of Biomedical Science and Technology (AiBST), key collaborator, Prof. Collen Masimirembwa; WHO; University of Zimbabwe, Universities of Zambia and Malawi